March 3 - CE Evening Lecture
This PDH lecture introduces the Solvent Redistribution (SR) method, based on second harmonic scattering (SHS)—a nonlinear optical technique that detects nanoscale changes in the solvent as the molecules begin to aggregate. Using a model that connects the statistical mechanics of aggregation with nonlinear optical theory, we show that solvent redistribution and interfacial fluctuations around solute clusters provide a sensitive optical handle to track solubility and early aggregation. We then demonstrate how SR can be implemented in a plate-based format for high-throughput measurements, substantially reducing compound consumption, waste, and energy use compared with traditional HPLC-based solubility workflows. Overall, SR addresses a key bottleneck in drug discovery and development, where existing approaches are either accurate but slow and resource-intensive, or fast but often unreliable.
Our speaker, Orly Tarun, PhD, is the CEO and founder of ORYL Photonics SA, a spin-off from EPFL (École Polytechnique Fédérale de Lausanne), Switzerland, where he earned his doctorate in Photonics. His doctoral research focused on the development of a wide-field second harmonic microscope with over a 1000× improvement in signal-to-noise ratio compared with existing nonlinear microscopes. Using this platform, he imaged the ~1 nm hydration layer adjacent to freestanding planar lipid bilayers thinner than 10 nm. He received the EPFL Thesis Distinction in Photonics and is passionate about technology development and entrepreneurship.
Tuesday, March 3, 2026 (Time in EDT)
5:30pm-6:30pm – Presentation
6:30pm-6:45pm – Q&A Session & Closing Remarks
Price:
$15 Virtual Option Only
Virtual information will be provided to virtual attendees the morning of the event.
PDH Potential: 1 Credit
Lecture Details:
PDH Info & Registration Page
Register by noon on Tuesday, March 3rd to ensure your spot is saved! |